Our goal is to develop a disease modifying therapeutic vaccine for the treatment, and prevention of the progression, of Alzheimer’s disease. A long-acting and cost-efficient drug will make it possible for patients to lead an independent life without impact from the disease.
“We have initiated the first clinical trial with a therapeutic vaccine that specifically targets the toxic oligomers of amyloid-β in patients with Alzheimer’s disease”
– Kristina Torfgård, CEO, Alzinova
The future looks bright
We are proud of our research and are dedicated to deliver a therapeutic oligomer-specific vaccine against Alzheimer’s disease. It is a unique vaccine that makes the body generate its own antibodies that target only the toxic oligomers of amyloid-β (Aβ), which are believed to be the cause of Alzheimer’s disease — a disease that is one of the most common and devastating neurological diseases globally, today afflicting over 30 million people.
Alzinova’s lead candidate, ALZ-101, is being developed as a therapeutic vaccine for the treatment of Alzheimer’s disease. The vaccine is in clinical development with a phase 1b study in Alzheimer’s patients. This marks the first study with ALZ-101 on humans, and will thus be a so-called safety study, where the objective is to demonstrate safety and good tolerability of the therapeutic vaccine ALZ-101 in patients with Alzheimer’s disease. In the clinical study, we will also examine the patients’ immune response, as well as a number of different biological markers that are associated with Alzheimer’s disease. Recruitment to the phase 1b study was completed according to plan in December 2022 and results of the study are expected to be available in the second half of 2023.
A unique and highly specific therapeutic vaccine
Immunotherapeutic drug candidates, binding to aggregated Aβ, is the only type of therapy that has shown positive effects in clinical trials. Our drug candidate ALZ-101 and the ALZ-201 antibody differ from previously tested candidates against Alzheimer’s disease, which bind non-specifically and to differing degrees to various forms of Aβ. Completed clinical trials on other candidates indicate that the specificity matters, to achieve efficacy as well as to avoid adverse side effects.
ALZ-101 is unique and a highly specific therapeutic vaccine, directed towards the toxic form of oligomeric Aβ. It has the opportuniy to become an effective treatment to halt and prevent the progression of Alzheimer’s disease.
Learn more about Alzheimer’s disease, our programs and the potential of our unique proprietary AβCC technology.
Learn more about the Alzinova portfolio and our proprietary AβCC Peptide™ Technology. Read more
Learn more about the causes of Alzheimer’s and the potential in our oligomer specific immunotherapy. Read more