Oligomer-Targeting Drug Development Programs
We are dedicated to developing novel disease-modifying treatments that target the toxic amyloid-β oligomers specifically. Alzinova’s lead candidate, ALZ-101, is in late preclinical development, and ALZ-201 is entering clinical development. The portfolio is generated from the proprietary AβCC Peptide™ Technology.
ALZ-101 is a vaccine that stimulates the production of antibodies against the toxic Aβ oligomers. It has completed the preclinical phase. A first-in-human study in patients with early Alzheimer’s disease is about to start.
Several clinical setbacks within anti-amyloid methods to treat Alzheimer’s disease have highlighted that non-clinical in vivo efficacy studies in transgenic disease models alone cannot prove a drug’s potential. Alzinova has therefore complemented the early selection process with in vitro and ex vivo pharmacology studies utilizing patient-derived toxic material.
In brief, the selection of ALZ-101 was based on three important criteria:
- Specificity for the CNS-specific oligomeric forms has been demonstrated in vitro.
- Information of potential efficacy has been obtained by assessing the direct toxic effect(s) of brain material, and neutralizing this effect ex vivo.
- Target engagement in the CNS has been demonstrated in vivo using a preclinical efficacy model (transgenic mice) which focused on relevant markers of oligomer-pathology.
This combined information serve as a good indicator of ALZ-101’s potential efficacy.
ALZ-101 has also proven to be immunogenic. It generates an immune response that is not associated with any findings suggestive of systemic toxicity in mice, rabbits and non-human primates. A GLP-compliant toxicology and safety pharmacology study in non-human primates demonstrated that it was clinically well tolerated in this species.
Alzinova has designed a first-in-human clinical study to evaluate the safety and immunogenicity of ALZ-101. Exploratory endpoints are biomarkers in cerebrospinal fluid (CSF) and serum and preliminary efficacy measured with a package of psychometric tests.
The study is just about to start recruitment.
ALZ-201 is a monoclonal antibody that is specific for the toxic Aβ oligomers. ALZ 201 is currently in preclinical development.
ALZ-201 was developed using ALZ-101. It is a murine monoclonal antibody of IgG type that is extremely specific for the Aβ42CC oligomers. It completely lacks affinity for monomers, fibrils and all forms of Aβ40. It does not bind the plaques of humans.
Immuodepletion of brain extracts demonstrates that the native Aβ targeted by this antibody is not detectable using Western blots. Despite this, it has a profound effect on the toxicity of the brain extracts, indicating that the amounts of toxic Aβ42 in patient brains are very low.
ALZ-201 is thus a novel antibody with a specificity that differs from known antibodies, and further substantiates that there are oligomer-specific epitopes in full-length Aβ42 that can be targeted with very high specificity without also targeting monomers and fibrils.
Learn more about the causes of Alzheimer’s and the potential in our oligomer specific immunotherapy. Read more
Specific Targeting of Toxic Aβ Oligomers
Learn more about how Alzinova develops therapies that target Aβ oligomers specifically. Read more